Pietzsch JB, Garner A, McQueen M. Economic impact of changes in neonatal intensive care unit ventilation strategies with the advent of new noninvasive ventilation techniques: a review and proposed assessment framework for high flow therapy as a routine respiratory support paradigm. JHEOR. 2015;3(1):34–42. https://doi.org/10.36469/9840

Objectives. High flow therapy (HFT) has been demonstrated to be a safe and effective noninvasive respiratory support technique for the treatment of pre-term infants in neonatal intensive care. Our objective was to develop a quantitative framework based on available evidence to estimate the economic impact of adopting an HFT respiratory support strategy, compared to current standard of care.

Methods. Model parameters were derived from a recent study comparing respiratory modality utilization among five US-based neonatal intensive care units (NICUs) adopting an HFT strategy with a larger pool of NICUs in the Vermont-Oxford Network, and from single center experience. We computed the total cost difference between the respiratory support strategies based on published cost data. Parameter uncertainty was tested in sensitivity analyses.

Results. The constructed model projected expected cost savings of $2,317 for the HFT strategy for the base case. Results were sensitive to the cost of HFT and to the duration of HFT use, duration of conventional mechanical ventilation, and duration of nasal continuous positive airway pressure support.

Conclusions. Adoption of an HFT strategy appears to be associated with meaningful savings in total NICU episode-of-care costs, primarily because of reductions in the duration of conventional mechanical ventilation. Further research is warranted to substantiate these findings.